Opportunity Information: Apply for CDC RFA GH21 2169
The grant opportunity "Strengthening detection, prevention and response to infectious disease threats in Uzbekistan" (Funding Opportunity Number: CDC RFA GH21 2169) is a CDC-funded cooperative agreement under the U.S. Department of Health and Human Services, aimed at building Uzbekistan's public health laboratory and surveillance capacity. It is positioned as a continuation and expansion of work already underway at the Research Institute for Epidemiology, Microbiology and Infectious Diseases (RIEMID) under a prior CDC cooperative agreement focused on antimicrobial resistance (AMR). RIEMID is also formally recognized by the Government of Uzbekistan as a national center for genetic technologies under Presidential Decree PP-4790 (July 27, 2020), which sets the backdrop for CDC to deepen support around advanced laboratory genomics and national surveillance functions.
A central focus of the opportunity is the establishment of a Center for Genome Sequencing of Emerging and Re-Emerging Infectious Diseases at RIEMID. The intent is explicitly non-research and practical: CDC seeks to help RIEMID stand up and operationalize a sequencing program that can be used routinely for public health action. The activities described include training and mentorship for staff working at the new Center, procurement of specialized gene sequencing equipment, transfer and sharing of established pathogen sequencing methodologies, support for analyzing sequencing data, and building an understanding of why sharing genomic data with the global community matters. In other words, the award is designed to move beyond one-off sequencing and toward a sustainable, standardized capability where staff can generate, interpret, and communicate genomic results in ways that inform surveillance and response.
COVID-19 response capacity is a key driver of the sequencing component. By developing in-country genomic sequencing, Uzbekistan would be better equipped to detect, investigate, and report SARS-CoV-2 transmission patterns, including the ability to identify new strains and monitor mutations as they emerge. The opportunity emphasizes that sequencing data can clarify pathogen phylogeny, meaning it helps map how viruses and other pathogens evolve and spread over time. That kind of information can strengthen outbreak investigations, improve situational awareness for public health decision-making, and potentially contribute to vaccine-related efforts by improving understanding of circulating variants, especially if data are shared in ways that benefit both Uzbekistan and the broader international public health community.
Alongside genomics for emerging infections, the grant continues to prioritize antimicrobial resistance as a major infectious disease threat. CDC indicates it wants RIEMID to extend AMR surveillance to cover the entire country, not just selected sites or regions, suggesting a shift toward more comprehensive national coverage and more consistent reporting. The opportunity also calls for non-research activities that strengthen the rational use of antimicrobials, which typically refers to stewardship-oriented approaches that reduce unnecessary antibiotic use and help slow the development and spread of resistance. This part of the scope points to a broader strategy that connects laboratory surveillance (detecting resistance) with system-level interventions (reducing misuse and overuse).
The grant further highlights modernizing bacterial identification and AMR detection by introducing genetic surveillance and rapid identification systems such as MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight). MALDI-TOF is widely used to identify bacteria quickly and accurately in clinical and reference laboratories, which can improve turnaround time, support better patient management, and strengthen surveillance data quality. In addition, CDC underscores the importance of improving AMR data quality through implementation of a quality management system (QMS) in bacteriology laboratories. This implies work on standard operating procedures, quality control, staff competency, documentation practices, and consistency across laboratories, so that AMR data are reliable and comparable. Finally, the opportunity calls for consolidating AMR data within the RIEMID AMR reference center, indicating an intent to strengthen central coordination, data aggregation, and national-level analysis and reporting.
Administratively, this funding opportunity is listed as discretionary and uses a cooperative agreement mechanism, meaning CDC expects to have substantial involvement beyond simple grantmaking, typically through technical collaboration, guidance, and ongoing engagement. The activity category is health (CFDA number 93.318). The posting indicates an expected single award (ExpectedAwards: 1), suggesting the work is designed around a specific partner and national implementation pathway rather than a broad competitive pool. The opportunity was created May 11, 2021, with an original closing date of July 10, 2021, and applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date. The listed award ceiling is shown as 0 in the source data, which often means the ceiling was not specified in that field rather than indicating no funding, and the eligibility category is presented as "Others" with additional eligibility clarification referenced in the full announcement.
Overall, the opportunity is aimed at building lasting national capacity in Uzbekistan by pairing infrastructure investments (sequencing and lab equipment) with workforce development (training and mentorship), standardized methods (shared protocols and analytics approaches), stronger quality systems (QMS in bacteriology labs), and improved national coordination (consolidated AMR data and expanded surveillance). The intended end state is a stronger, faster, and more reliable ability to detect infectious disease threats like COVID-19 variants and antimicrobial-resistant organisms, and to translate laboratory findings into public health action and reporting that aligns with global best practices.Apply for CDC RFA GH21 2169
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Strengthening detection, prevention and response to infectious disease threats in Uzbekistan" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.318.
- This funding opportunity was created on May 11, 2021.
- Applicants must submit their applications by Jul 10, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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