Opportunity Information: Apply for HT942524TSCRPCTRA
The DoD Tuberous Sclerosis Complex (TSC) Clinical Translational Research Award (CTRA) is a U.S. Army Medical Research acquisition activity grant opportunity designed to push credible TSC research closer to real-world clinical use. The core aim is translation: taking promising and well-supported findings from preclinical and/or clinical work and moving them toward practical applications that can improve how TSC is diagnosed, how outcomes are predicted (prognosis), or how the disease is treated. The program is positioned for projects that can clearly explain the clinical path forward, not basic exploration for its own sake.
The types of projects encouraged under this award span several translational lanes. One major lane is bidirectional translational work, meaning studies that move from preclinical evidence into human testing, or that loop back from clinical observations to refine or validate mechanisms in preclinical systems. This includes research that analyzes human anatomical substances (such as biospecimens) and/or data connected to completed clinical trials, especially when that analysis can clarify mechanism of action or lead to better diagnostic tools, prognostic models, or treatment strategies. Another lane focuses on improving clinical trial readiness, such as developing and qualifying biomarkers, refining clinical endpoints that are meaningful and measurable, and validating pharmacokinetics and pharmacodynamics so that dosing, exposure, and biological effect are understood well enough to support later-stage trials.
The announcement also allows pilot clinical trials. These are limited, early clinical tests (often small sample sizes) of novel interventions intended to produce preliminary evidence about effectiveness, safety, tolerability, or biological mechanism. The point is not to run a large definitive trial, but to generate strong early data that can justify the next step in development and ultimately contribute to interventions that measurably improve outcomes for people with TSC. In addition, the award explicitly supports studies aimed at improving clinical care using existing real-world clinical practice data. That could include analyses that inform or refine guidelines and care pathways in practical areas aligned with the FY24 TSC Research Program focus areas, with examples given such as epilepsy surgery, tumor resection, reproductive health, and perinatal surveillance and care.
A key boundary in the solicitation is that projects must include a clinical component. Preclinical work can be included and may be appropriate when it is directly tied to clinical translation, but proposals that are strictly animal research are not eligible for this mechanism and are directed to consider other FY24 TSCRP opportunities instead. In other words, the CTRA is meant for research that touches human data, human samples, clinical testing, clinical endpoints, or clinical practice in a way that makes the translational relevance unmistakable.
Administratively, this is a discretionary grant opportunity (Funding Opportunity Number HT942524TSCRPCTRA) under CFDA 12.420, offered by the Department of the Army through USAMRAA. Eligibility is listed as unrestricted, and the original application closing date is August 1, 2024. The notice anticipates making about two awards, and while an award ceiling is referenced, the provided source text does not specify a dollar amount.Apply for HT942524TSCRPCTRA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex, Clinical Translational Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2024-04-19.
- Applicants must submit their applications by 2024-08-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted.
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