Opportunity Information: Apply for RFA DK 27 109
The NIH is offering a single-source cooperative agreement to continue operating and expanding the Resource Center for the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D). The core aim of CaRe-T1D is to speed up discovery and mechanistic research by enabling scientists to study well-characterized human cardiovascular tissue from people with type 1 diabetes. By building and sharing these human tissue resources, the program is meant to sharpen understanding of why cardiovascular disease is such a major cause of illness and death in type 1 diabetes, how those pathways may differ from cardiovascular disease in type 2 diabetes, and how that knowledge can be translated into better targeted therapies.
This award supports a U24 cooperative agreement, meaning NIH will have substantial involvement and the funded group will be expected to work closely with NIH and with the broader CaRe-T1D consortium. The Resource Center is expected to do several interconnected jobs: expand the biorepository of human cardiovascular tissues (so that more samples are available and better represent relevant disease states), continue to develop and maintain a data commons that supports modern data sharing and the use of AI-enabled tools, coordinate the scientific and operational activities across participating investigative teams, and make CaRe-T1D resources accessible beyond the immediate consortium so other qualified researchers can use the tissue and data for additional studies. The NOFO explicitly states that clinical trials are not allowed under this mechanism.
The opportunity is tied to the Special Diabetes Program, a congressionally supported NIH effort focused on preventing, treating, and curing type 1 diabetes and addressing its complications. In practice, that connection signals that the repository and its data infrastructure are intended to function as a long-term, community-facing platform that enables collaborative and high-impact research, rather than a one-off project limited to a single lab. The work is oriented toward understanding disease mechanisms in human tissue, building tools and infrastructure for broad reuse, and coordinating collaborative science at a consortium scale.
This is a true single-source competition: only the University of Florida is eligible to apply, and foreign organizations are not eligible. In addition, foreign components of U.S. organizations are not allowed, and foreign components as defined in the NIH Grants Policy Statement are prohibited. Although the general funding listing may show many standard NIH applicant categories, the NOFO makes clear that eligibility for this specific solicitation is restricted to the named single source applicant.
Key administrative details include: the funding opportunity number is RFA-DK-27-109, the sponsor is the National Institutes of Health, the instrument is a cooperative agreement (U24), and the application deadline is September 30, 2026. NIH expects to make one award, with an award ceiling of $1,500,000. As with standard NIH practice, the application will still go through peer review, and only an application judged meritorious will be considered for funding.Apply for RFA DK 27 109
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Source Competition: Continuation of the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) - Resource Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.310, 93.837, 93.838, 93.839, 93.840, 93.847.
- This funding opportunity was created on 2026-06-04.
- Applicants must submit their applications by 2026-09-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is this NIH funding opportunity?
This opportunity is an NIH Notice of Funding Opportunity (NOFO) for a single-source cooperative agreement to continue operating and expanding the Resource Center for the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D).
What is the main goal of CaRe-T1D?
The core aim is to speed up discovery and mechanistic research by enabling scientists to study well-characterized human cardiovascular tissue from people with type 1 diabetes. The program is designed to strengthen understanding of cardiovascular disease (CVD) in type 1 diabetes, how it may differ from CVD in type 2 diabetes, and how insights from human tissue can be translated into better targeted therapies.
What funding mechanism is being used?
The award supports a U24 cooperative agreement. In a cooperative agreement, NIH has substantial involvement, and the awardee is expected to work closely with NIH and with the broader CaRe-T1D consortium.
What does "substantial NIH involvement" mean for the project?
Based on the NOFO description of a U24 cooperative agreement, the funded group should expect active collaboration with NIH and ongoing coordination with the CaRe-T1D consortium rather than operating as a standalone project.
What kinds of activities is the CaRe-T1D Resource Center expected to perform?
The Resource Center is expected to carry out multiple interconnected functions, including:
- Expanding the biorepository of human cardiovascular tissues so more samples are available and better represent relevant disease states.
- Continuing to develop and maintain a data commons that supports modern data sharing and the use of AI-enabled tools.
- Coordinating scientific and operational activities across participating investigative teams.
- Making CaRe-T1D resources accessible beyond the immediate consortium so other qualified researchers can use tissue and data for additional studies.
Is this opportunity focused on building infrastructure or on one specific research project?
The opportunity is oriented toward building and sustaining shared resources and infrastructure (a tissue biorepository and a data commons) and coordinating collaborative science at a consortium scale, with an emphasis on broad reuse by the research community.
What kinds of research does CaRe-T1D enable?
CaRe-T1D is intended to enable mechanistic research using well-characterized human cardiovascular tissue from people with type 1 diabetes, supporting studies aimed at understanding disease pathways and differences compared to cardiovascular disease in type 2 diabetes, with the longer-term goal of informing better targeted therapies.
Are clinical trials allowed under this NOFO?
No. The NOFO explicitly states that clinical trials are not allowed under this mechanism.
How does this opportunity relate to the Special Diabetes Program?
The opportunity is tied to the Special Diabetes Program, described as a congressionally supported NIH effort focused on preventing, treating, and curing type 1 diabetes and addressing its complications. This connection signals an intent for the repository and its data infrastructure to function as a long-term, community-facing platform that enables collaborative and high-impact research.
Who is eligible to apply?
This is a true single-source competition. Only the University of Florida is eligible to apply.
Are foreign organizations eligible to apply?
No. Foreign organizations are not eligible.
Are foreign components allowed as part of a U.S. applicant organization?
No. Foreign components of U.S. organizations are not allowed, and foreign components (as defined in the NIH Grants Policy Statement) are prohibited under this solicitation.
Does the NOFO allow eligibility beyond the named applicant even if general NIH categories appear in listings?
No. While general funding listings may show standard NIH applicant categories, the NOFO states that eligibility for this specific solicitation is restricted to the named single source applicant (the University of Florida).
What is the funding opportunity number?
The funding opportunity number is RFA-DK-27-109.
Who is the sponsor?
The sponsor is the National Institutes of Health (NIH).
What is the application deadline?
The application deadline is September 30, 2026.
How many awards does NIH expect to make?
NIH expects to make one award.
What is the maximum award amount mentioned?
The opportunity lists an award ceiling of $1,500,000.
Will applications still be peer reviewed even though this is single-source?
Yes. The application will still go through peer review, and only an application judged meritorious will be considered for funding.
What is the intended impact of expanding the tissue biorepository?
Expanding the biorepository is intended to increase the availability of human cardiovascular tissue samples and improve representation of relevant disease states, making the resource more useful for a wider range of mechanistic studies.
What is the purpose of the CaRe-T1D data commons?
The data commons is meant to support modern data sharing and the use of AI-enabled tools, helping researchers work with CaRe-T1D data more effectively and enabling broader reuse of the resource.
Will CaRe-T1D resources be available to researchers outside the consortium?
Yes. A stated expectation is to make CaRe-T1D resources accessible beyond the immediate consortium so other qualified researchers can use the tissue and data for additional studies.
Browse more opportunities from the same category: Health
Next opportunity: OVW Fiscal Year 2026 Legal Assistance for Victims of Domestic Violence, Dating Violence, Stalking, and Sexual Assault Grant Program
Previous opportunity: Office of Elementary and Secondary Education (OESE): Office of Indian Education (OIE): State Tribal Education Partnership (STEP) Grant Program; Assistance Listing Number 84.415A
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DK 27 109
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DK 27 109) also looked into and applied for these:
| Funding Opportunity |
|---|
| Ryan White HIV/AIDS Program Part D Coordinated HIV Services and Access to Research for Women, Infants, Children, and Youth (WICY) Existing Geographic Service Areas Apply for HRSA 26 067 Funding Number: HRSA 26 067 Agency: Health Resources and Services Administration Category: Health Funding Amount: $2,000,000 |
| Rural Health Research Dissemination Program Apply for HRSA 26 049 Funding Number: HRSA 26 049 Agency: Health Resources and Services Administration Category: Health Funding Amount: $230,000 |
| Technology-enabled Collaborative Learning Program Apply for HRSA 26 053 Funding Number: HRSA 26 053 Agency: Health Resources and Services Administration Category: Health Funding Amount: $475,000 |
| 988 Suicide and Crisis Lifeline Crisis Center Follow-Up Programs Apply for FG 26 004 Funding Number: FG 26 004 Agency: Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $250,000 |
| FY2026 Support for 988 Tribal Response Cooperative Agreements Apply for FG 26 003 Funding Number: FG 26 003 Agency: Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $1,500,000 |
| Cooperative Agreements for States and Territories to Improve Local 988 Capacity Apply for FG 26 002 Funding Number: FG 26 002 Agency: Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $20,195,467 |
| NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional) Apply for RFA RM 27 003 Funding Number: RFA RM 27 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advancing Outbreak Detection, Notification, and Response Capacity by Implementing 7-1-7 in Partner Countries Apply for CDC RFA JG 26 0214 Funding Number: CDC RFA JG 26 0214 Agency: Centers for Disease Control-GHC Category: Health Funding Amount: Case Dependent |
| State Offices of Rural Health Program Apply for HRSA 26 065 Funding Number: HRSA 26 065 Agency: Health Resources and Services Administration Category: Health Funding Amount: $223,410 |
| Accelerating Discovery through Partnered Research with All of Us to Analyze Participant Biospecimens (X01 Clinical Trial Not Allowed) Apply for PAR 27 069 Funding Number: PAR 27 069 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed) Apply for PA 27 036 Funding Number: PA 27 036 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed) Apply for PAR 27 071 Funding Number: PAR 27 071 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Ryan White HIV/AIDS Program Part C Capacity Development Program Apply for HRSA 26 061 Funding Number: HRSA 26 061 Agency: Health Resources and Services Administration Category: Health Funding Amount: $150,000 |
| Institutional Mentored Career Development Award (Parent K12) (Clinical Trials Not Allowed) Apply for PA 27 030 Funding Number: PA 27 030 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Emergency Medical Services for Children (EMSC) National Pediatric Readiness Coordinating Center Cooperative Agreement Apply for HRSA 26 051 Funding Number: HRSA 26 051 Agency: Health Resources and Services Administration Category: Health Funding Amount: $4,200,000 |
| Rural Community Health Support Program Apply for HRSA 26 083 Funding Number: HRSA 26 083 Agency: Health Resources and Services Administration Category: Health Funding Amount: $4,500,000 |
| Delta Rural Integrated Health Network Program Apply for HRSA 26 073 Funding Number: HRSA 26 073 Agency: Health Resources and Services Administration Category: Health Funding Amount: $350,000 |
| Dental Faculty Loan Repayment Program (DFLRP) Apply for HRSA 26 066 Funding Number: HRSA 26 066 Agency: Health Resources and Services Administration Category: Health Funding Amount: $100,000 |
| Strategies to Link, Engage, and Retain Men with HIV in Care: Implementation Technical Assistance Provider Apply for HRSA 26 088 Funding Number: HRSA 26 088 Agency: Health Resources and Services Administration Category: Health Funding Amount: $3,240,000 |
| Strategies to Link, Engage, and Retain Men with HIV in Care: Evaluation Provider Apply for HRSA 26 087 Funding Number: HRSA 26 087 Agency: Health Resources and Services Administration Category: Health Funding Amount: $1,300,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DK 27 109", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.