Opportunity Information: Apply for RFA NS 17 024
The Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) (U24) funding opportunity (RFA-NS-17-024) is a cooperative agreement issued by the National Institute of Neurological Disorders and Stroke (NINDS) within the NIH. Its main goal is to support a set of clinical research sites that can participate in NeuroNEXT, a standing national network designed to efficiently develop and run multiple neuroscience clinical studies and exploratory trials. Rather than funding a single disease-specific project, this mechanism helps maintain site readiness and performance so the network can rapidly launch well-designed studies across a range of neurological disorders as promising therapies and research questions emerge.
A key emphasis of the program is conducting scientifically rigorous, exploratory clinical trials that can move the field toward more definitive testing. The FOA highlights examples such as Phase 2 clinical trials, as well as clinical research efforts focused on validating biomarkers and clinical outcome measures that are needed before larger confirmatory trials can be successful. In practice, this means the network is positioned to test interventions and approaches coming from academic labs, foundations, or industry partners, including studies that may be biomarker-informed (for example, selecting participants based on biological signals or using biomarkers to measure treatment response). The larger purpose is to improve the speed, consistency, and quality of multicenter neuroscience trials by relying on experienced, well-coordinated sites that share processes and expectations.
The award is structured as a cooperative agreement (U24), which generally signals substantial NIH involvement compared with a standard grant. Under this model, funded sites are expected to work closely with NINDS and the NeuroNEXT network leadership on planning and executing trials, following common protocols and operational standards. The intent is to create a coordinated infrastructure where each clinical site can contribute to participant recruitment, study conduct, and high-quality data collection across multiple studies over time, rather than building a new trial infrastructure from scratch for every new protocol.
Eligibility is broad and includes many types of organizations that can function as clinical research sites. Eligible applicants include state, county, and local governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); tribal governments and tribal organizations; public housing authorities/Indian housing authorities; and other entities as allowed by the FOA’s additional eligibility language. This range reflects the program’s focus on enrolling capable clinical sites wherever they exist, provided they can meet the operational demands of network-based, multicenter neuroscience studies.
From an administrative and funding perspective, the opportunity falls under the Health activity category and is associated with CFDA 93.853. The FOA information indicates an anticipated number of awards of about 25, with an award ceiling of $200,000. The posting lists a creation date of June 30, 2017, and an original closing date of September 1, 2017. Overall, the opportunity is best understood as a way for NINDS to maintain and expand a ready-to-activate network of high-performing clinical sites capable of running multiple, coordinated neuroscience clinical trials and biomarker/outcome validation studies, accelerating the translation of promising therapeutic ideas into well-executed human research.Apply for RFA NS 17 024
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on Jun 30, 2017.
- Applicants must submit their applications by Sep 01, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 25 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) (U24)" and is associated with FOA number RFA-NS-17-024.
Which federal agency and institute are offering this opportunity?
This is a cooperative agreement issued by the National Institute of Neurological Disorders and Stroke (NINDS) within the National Institutes of Health (NIH).
What is NeuroNEXT?
NeuroNEXT is a standing national network designed to efficiently develop and run multiple neuroscience clinical studies and exploratory trials. It is intended to support coordinated, multicenter work across a range of neurological disorders.
What is the main goal of this program?
The main goal is to support a set of clinical research sites that can participate in NeuroNEXT by maintaining site readiness and performance, so the network can rapidly launch well-designed studies as new therapies and research questions emerge.
Does this program fund a single disease-specific research project?
No. Rather than funding one disease-specific project, this mechanism supports clinical research sites as part of an ongoing network, enabling the sites to contribute to multiple studies over time.
What types of studies does the FOA emphasize?
The FOA emphasizes scientifically rigorous, exploratory clinical trials and related clinical research activities that help move the field toward more definitive testing. Examples highlighted include Phase 2 clinical trials and efforts focused on validating biomarkers and clinical outcome measures.
What is meant by "exploratory clinical trials" in this context?
In this context, exploratory trials are designed to efficiently test promising interventions or approaches and generate evidence needed to justify or design larger, confirmatory trials. The FOA points to Phase 2 trials as an example.
What role do biomarkers and outcome measures play in this program?
The network may conduct clinical research focused on validating biomarkers and clinical outcome measures. These tools are described as important prerequisites for successful larger confirmatory trials.
Can studies be biomarker-informed?
Yes. The FOA describes studies that may be biomarker-informed, such as selecting participants based on biological signals or using biomarkers to measure treatment response.
Where might the interventions or research questions come from?
The program is positioned to test interventions and approaches originating from academic laboratories, foundations, or industry partners.
What is the intended advantage of using a standing network like NeuroNEXT?
The intent is to improve the speed, consistency, and quality of multicenter neuroscience trials by relying on experienced, well-coordinated sites that share processes and expectations, rather than creating a new trial infrastructure for each new protocol.
What does the U24 cooperative agreement mechanism imply?
U24 indicates a cooperative agreement, which generally signals substantial NIH involvement compared with a standard grant. Funded sites are expected to work closely with NINDS and NeuroNEXT network leadership on planning and executing trials and to follow common protocols and operational standards.
What are funded sites expected to do as part of the network?
Funded sites are expected to contribute to participant recruitment, study conduct, and high-quality data collection across multiple studies over time, operating within coordinated network processes and standards.
Who is eligible to apply?
Eligibility is broad and includes organizations that can function as clinical research sites. Eligible applicants include state, county, and local governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); tribal governments and tribal organizations; public housing authorities/Indian housing authorities; and other entities as allowed by the FOA's additional eligibility language.
Is this opportunity limited to nonprofits or universities?
No. The eligibility list includes nonprofits, multiple types of higher education institutions, government entities, tribal entities, and for-profit organizations, reflecting an emphasis on capable clinical research sites across many organizational types.
What activity category is this opportunity associated with?
The opportunity falls under the Health activity category.
What CFDA number is associated with this opportunity?
The associated CFDA number is 93.853.
How many awards were anticipated?
The FOA indicates an anticipated number of awards of about 25.
What is the award ceiling listed for this opportunity?
The posting lists an award ceiling of $200,000.
What were the key dates listed in the posting?
The posting lists a creation date of June 30, 2017, and an original closing date of September 1, 2017.
How should applicants think about the purpose of this opportunity overall?
Overall, it is best understood as a way for NINDS to maintain and expand a ready-to-activate network of high-performing clinical sites capable of running multiple coordinated neuroscience clinical trials and biomarker/outcome validation studies, accelerating translation of promising ideas into well-executed human research.
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